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锟斤拷锟斤拷锟斤拷锟剿撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟轿ｏ拷锟界不锟斤拷锟斤拷锟斤拷锟竭ｏ拷锟诫将锟斤拷锟斤拷症状锟斤拷锟斤拷锟介、锟斤拷椤拷锟斤拷锟斤拷锟较诧拷锟斤拷锟斤拷锟较ｏ拷锟斤拷锟斤拷锟斤拷通讯锟斤拷址锟斤拷锟界话锟斤拷锟斤拷锟斤拷锟斤拷锟截ｏ拷锟斤拷印锟斤拷锟斤拷锟斤拷锟斤拷锟芥到专锟斤拷锟介，锟斤拷专锟斤拷锟斤拷锟斤拷锟斤拷锟狡讹拷锟斤拷锟斤拷锟狡凤拷锟斤拷锟斤拷锟劫凤拷锟斤拷锟斤拷锟斤拷锟剿★拷通锟斤拷锟绞寄凤拷式锟斤拷锟斤拷锟斤拷锟狡★拷锟斤拷锟斤拷锟叫匡拷锟斤拷时锟斤拷询专锟斤拷锟介。
锟斤拷锟斤拷专锟斤拷锟介：
010-80725845
69733109
锟斤拷锟绞拷枪亟诓锟阶拷锟斤拷椋�
010-80725844
80725845
锟角达拷锟斤拷锟斤拷锟街拷锟阶拷锟斤拷椋�
010-69733115
69733109
锟轿诧拷专锟斤拷锟介：
010-69733109
80725845 |
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锟斤拷锟斤拷维锟斤拷(锟斤拷)
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锟斤拷锟竭ｏ拷锟斤拷 锟斤拷
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锟斤拷锟斤拷锟斤拷锟斤拷维锟斤拷锟斤拷Fibrosis锟斤拷锟斤拷指锟斤拷锟斤拷锟斤拷维锟斤拷锟斤拷锟街拷墓锟斤拷瘸锟斤拷锟斤拷锟斤拷锟斤拷锟轿拷锟斤拷锟斤拷锟� Fibrogenesis锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷屎铣锟斤拷锟斤拷樱锟斤拷锟斤拷锟轿拷纸猓‵ibrolysis锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷式锟斤拷猓╋拷锟狡斤拷锟侥斤拷锟斤拷锟斤拷锟轿拷锟斤拷锟斤拷腔锟斤拷锟斤拷锟斤拷锟斤拷锟剿碉拷一锟斤拷锟睫革拷锟斤拷应锟斤拷一锟斤拷锟叫猴拷锟斤拷锟斤拷去锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷食煞值玫锟斤拷指锟斤拷锟斤拷锟轿拷锟斤拷锟酵Ｖ癸拷锟斤拷锟斤拷约锟斤拷曰锟揭伙拷锟斤拷愿锟斤拷嗉诧拷锟斤拷锟绞癸拷锟斤拷锟斤拷锟揭诧拷锟斤拷岬硷拷赂锟斤拷锟轿拷锟斤拷锟斤拷锟斤拷锟斤拷植锟斤拷锟斤拷锟斤拷路锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆革拷实锟斤拷锟斤拷症锟斤拷锟斤拷锟斤拷锟缴碉拷锟铰革拷锟斤拷锟斤拷锟斤拷锟斤拷系锟斤拷锟轿拷锟斤拷锟斤拷锟斤拷纬筛锟斤拷锟轿拷锟斤拷锟斤拷锟角帮拷锟秸癸拷锟斤拷锟斤拷锟叫∫讹拷峁癸拷锟斤拷苹锟斤拷锟斤拷锟斤拷锟轿成硷拷锟斤拷为锟斤拷硬锟斤拷锟斤拷锟接革拷硬锟斤拷锟侥诧拷锟斤拷学锟侥讹拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆革拷锟斤拷维锟斤拷锟斤拷锟睫斤拷锟斤拷纬桑锟斤拷锟斤拷锟斤拷锟斤拷愿锟斤拷锟轿拷锟斤拷锟斤拷锟斤拷锟剿ワ拷锟斤拷锟斤拷碌母锟斤拷锟斤拷莸锟斤拷锟斤拷锟斤拷锟轿拷锟斤拷锟斤拷锟斤拷艹锟轿拷锟接诧拷锟斤拷锟斤拷锟斤拷薪锟斤拷锟轿成讹拷锟斤拷锟斤拷锟斤拷锟皆革拷锟斤拷维锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷越锟斤拷锟皆革拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷愿锟较革拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟揭诧拷锟斤拷歉锟接诧拷锟斤拷锟斤拷锟斤拷谴锟斤拷锟斤拷锟斤拷锟斤拷愿尾锟斤拷锟斤拷乇锟斤拷锟斤拷锟斤拷圆锟斤拷锟斤拷愿锟斤拷椎锟斤拷俅锟斤拷锟斤拷锟斤拷锟斤拷荼锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟轿拷锟斤拷透锟接诧拷锟斤拷锟斤拷锟斤拷锟斤拷姆锟秸癸拷锟斤拷蹋锟斤拷锟斤拷锟斤拷锟斤拷越锟饺伙拷挚锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟较革拷锟斤拷锟斤拷锟窖э拷头锟斤拷锟斤拷锟斤拷锟窖э拷锟窖革拷俜锟秸癸拷锟斤拷锟斤拷嵌愿锟斤拷锟较革拷锟斤拷锟斤拷锟绞碉拷锟斤拷伞锟斤拷锟叫伙拷锟斤拷锟斤拷锟斤拷锟窖э拷锟斤拷艿锟斤拷锟绞讹拷锟斤拷锟斤拷锟斤拷耄拷锟斤拷锟皆革拷锟斤拷维锟斤拷锟侥凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷虾锟斤拷锟斤拷频锟斤拷芯锟揭诧拷锟斤拷私洗锟侥斤拷展锟斤拷
一.细锟斤拷锟斤拷锟斤拷剩锟紼xtracellular Matrix,ECM锟斤拷锟斤拷锟斤拷杉锟斤拷锟斤拷谢锟斤拷锟斤拷锟斤拷学锟斤拷锟斤拷
细锟斤拷锟斤拷锟斤拷锟揭伙拷锟斤拷锟斤拷锟斤拷原锟斤拷锟角斤拷原锟角碉拷锟阶★拷锟斤拷锟阶讹拷锟角硷拷锟斤拷锟斤拷硬锟斤拷锟阶★拷锟斤拷锟斤拷锟斤拷锟铰的观点，ECM锟斤拷应锟斤拷锟斤拷锟斤拷锟绞斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷MMP锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷织锟斤拷锟斤拷锟斤（TIMP锟斤拷锟斤拷锟斤拷锟斤拷粘锟斤拷锟斤拷锟接ｏ拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷澹╋拷锟斤拷约锟斤拷锟斤拷锟绞成分达拷锟斤拷咏锟较的革拷锟斤拷锟斤拷锟斤拷锟斤拷锟接猴拷细锟斤拷锟斤拷锟接★拷锟斤拷锟斤拷锟斤拷为ECM锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟铰★拷锟斤拷锟斤拷支锟斤拷锟斤拷锟矫的撅拷态锟斤拷锟绞ｏ拷锟斤拷锟斤拷锟斤拷织锟斤拷锟津、达拷谢锟斤拷跃锟斤拷锟揭讹拷细锟斤拷锟斤拷锟斤拷织锟斤拷锟斤拷锟劫碉拷锟斤拷态锟斤拷锟斤拷锟斤拷锟斤拷锟街伙拷锟酵达拷谢锟饺结构锟酵癸拷锟斤拷锟斤拷锟斤拷要影锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷印锟�
锟斤拷一锟斤拷锟斤拷原锟斤拷Collagen锟斤拷
锟斤拷原锟斤拷细锟斤拷锟斤拷锟斤拷实锟斤拷锟斤拷锟揭拷煞郑锟侥壳帮拷逊锟斤拷锟斤拷锟斤拷锟�19锟酵伙拷锟斤拷锟斤拷锟叫诧拷同锟侥斤拷原锟斤拷锟节革拷锟斤拷锟杰猴拷锟斤拷锟较高碉拷锟斤拷5锟酵ｏ拷锟街憋拷为锟斤拷锟斤拷33%锟斤拷锟斤拷锟斤拷33%锟斤拷锟斤拷锟斤拷1%锟斤拷锟斤拷锟斤拷1%锟斤拷10%锟斤拷锟斤拷锟斤拷0.1%锟斤拷1%锟斤拷锟斤拷锟斤拷锟剿革拷锟斤拷慕锟皆拷锟斤拷锟皆嘉�5.5mg/g锟斤拷湿锟截ｏ拷锟斤拷/锟斤拷锟酵斤拷原锟侥憋拷为1:1锟斤拷锟斤拷锟斤拷维锟斤拷锟酵革拷硬锟斤拷时锟斤拷锟洁胶原锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟揭拷/锟斤拷锟酵的憋拷值锟斤拷锟接ｏ拷锟斤拷锟斤拷锟节此憋拷锟斤拷锟斤拷锟斤拷锟斤拷2.38锟斤拷锟斤拷锟捷斤拷原锟斤拷锟斤拷态锟酵结构锟截点及锟街诧拷锟斤拷位锟斤拷锟缴凤拷为锟斤拷锟斤拷锟洁：锟斤拷锟斤拷维锟皆斤拷原锟斤拷锟斤拷锟斤拷锟今、Ⅲ、拷锟斤拷锟斤拷锟酵ｏ拷锟斤拷锟酵斤拷原锟斤拷去锟斤拷C锟斤拷锟侥猴拷植锟斤拷锟窖拷锟斤拷围锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷为锟斤拷锟斤拷使锟今、拷锟酵斤拷原锟轿成粗达拷锟斤拷锟轿拷锟斤拷锟斤拷徒锟皆拷蚀锟斤拷锟斤拷锟斤拷峁癸拷植锟斤拷冖瘛ⅱ锟酵拷锟酵斤拷原锟轿成碉拷锟斤拷维锟斤拷之锟斤拷锟斤拷粘锟斤拷锟斤拷锟矫★拷锟节伙拷锟斤拷膜锟皆斤拷原锟斤拷锟斤拷锟斤拷锟酵斤拷原锟斤拷锟斤拷锟侥讹拷锟侥诧拷去锟斤拷锟斤拷锟角斤拷锟斤拷锟斤拷锟斤拷纬锟斤拷锟轿拷锟斤拷锟阶达拷峁癸拷锟斤拷锟揭拷植锟斤拷诟锟窖拷锟斤拷皮锟铰ｏ拷为锟斤拷细锟斤拷锟斤拷锟斤拷皮细锟斤拷锟斤拷锟杰伙拷锟斤拷膜锟斤拷锟斤拷要锟缴份★拷锟斤拷原锟侥合成诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟阶硷拷锟斤拷锟斤拷搿拷锟斤拷锟斤拷锟斤拷锟轿ｏ拷锟角伙拷锟斤拷锟斤拷锟角伙拷锟斤拷锟斤拷锟轿成︼拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟轿筹拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷原锟侥伙拷锟斤拷锟斤拷位-前锟斤拷原锟斤拷Precollagen锟斤拷锟斤拷锟斤拷微锟斤拷锟斤拷锟节碉拷细锟斤拷锟斤拷锟斤拷去N锟剿猴拷C锟斤拷锟侥猴拷锟洁互锟斤拷锟斤拷锟轿成斤拷原锟斤拷维锟斤拷锟斤拷锟斤拷状锟结构锟斤拷
锟斤拷锟斤拷锟斤拷锟角斤拷原锟角碉拷锟阶ｏ拷Noncollagenous Glycoproteins锟斤拷
锟斤拷细锟斤拷锟斤拷锟斤拷实锟斤拷锟揭伙拷锟揭拷锟街ｏ拷锟斤拷锟斤拷锟斤拷械亩锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷始锟斤拷锟斤拷锟较革拷锟侥わ拷目锟侥わ拷锟斤拷锟斤拷锟斤拷锟斤拷希锟斤拷佣锟接帮拷锟较革拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷只锟斤拷锟斤拷锟叫伙拷雀锟斤拷锟斤拷锟斤拷锟窖э拷锟轿拷锟斤拷锟斤拷锟斤拷锟杰多，锟斤拷锟斤拷要锟叫撅拷锟斤拷锟铰ｏ拷
1.锟斤拷维锟斤拷锟结蛋锟斤拷锟绞ｏ拷Fibrnectin锟斤拷
锟缴凤拷为血锟斤拷锟皆ｏ拷锟斤拷锟斤拷锟皆ｏ拷锟斤拷细锟斤拷锟皆ｏ拷锟斤拷锟斤拷锟皆ｏ拷锟斤拷前锟斤拷锟斤拷要锟缴革拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷要锟斤拷锟斤拷脂细锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷血锟斤拷锟斤拷皮细锟斤拷锟斤拷锟斤拷锟斤拷锟节革拷锟斤拷维锟斤拷锟斤拷锟斤拷锟戒含锟斤拷锟斤拷锟洁，锟斤拷为锟皆猴拷原锟斤拷锟斤拷锟斤拷支锟杰★拷
2.锟斤拷锟斤拷锟斤拷锟阶ｏ拷Laminin锟斤拷
锟斤拷锟斤拷锟斤拷锟斤拷锟角碉拷位锟斤拷一锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷傻摹锟绞拷锟斤拷锟斤拷徒峁癸拷锟斤拷锟斤拷锟斤拷锟节诧拷锟叫匡拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷透锟斤拷亟锟较的癸拷锟斤拷锟斤拷锟斤拷锟斤拷锟酵拷锟酵斤拷原一锟金构成伙拷锟斤拷膜锟斤拷锟斤拷要锟缴份ｏ拷锟街诧拷锟斤拷血锟杰★拷锟斤拷锟杰伙拷锟斤拷膜锟较ｏ拷锟斤拷血锟斤拷锟狡わ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷植锟斤拷锟斤拷锟斤拷锟斤拷维锟斤拷细锟斤拷锟侥分伙拷状态锟斤拷锟斤拷要锟斤拷锟藉。
3.细锟斤拷粘锟斤拷锟截ｏ拷Tenascins,Cytotactin,Bronionectin,Hexabronchions锟斤拷
锟斤拷锟斤拷6锟斤拷锟斤拷同锟斤拷锟角碉拷位锟斤拷傻锟斤拷锟斤拷锟斤拷澹拷锟斤拷锟街革拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟轿拷锟斤拷浅锟斤拷锟斤拷锟较革拷锟斤拷锟斤拷锟斤拷锟斤拷氐锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷刖诧拷锟斤拷锟轿э拷锟较革拷锟斤拷锟轿拷锟斤拷锟叫ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷ECM锟侥筹拷锟斤拷锟斤拷锟斤拷锟斤拷锟矫★拷
4.锟斤拷锟斤拷维锟斤拷锟斤拷锟截ｏ拷Undulin锟斤拷
锟斤拷3锟斤拷锟角伙拷锟斤拷桑锟斤拷涞ワ拷锟酵诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟狡ｏ拷锟斤拷锟斤拷一锟斤拷锟教臂ｏ拷锟斤拷要锟街憋拷锟节斤拷锟斤拷锟斤拷锟叫的Ⅰ、拷锟酵斤拷原锟斤拷维锟叫ｏ拷锟斤拷锟斤拷维锟街斤拷原锟侥筹拷锟斤拷锟接结构锟斤拷锟斤拷要锟斤拷锟矫ｏ拷锟斤拷细锟斤拷锟斤拷源锟叫诧拷锟斤拷锟剿★拷
5.血栓粘锟斤拷锟截ｏ拷Thrombospondin锟斤拷
锟斤拷3锟斤拷锟斤拷同锟角伙拷锟斤拷末锟斤拷锟斤拷锟斤拷锟斤拷锟轿筹拷一锟斤拷小锟斤拷锟藉，锟杰斤拷细锟斤拷亍锟斤拷锟斤拷徒锟皆拷锟斤拷锟轿拷锟斤拷岬帮拷住锟窖拷锟斤拷锟斤拷锟矫冈拷锟斤拷锟轿拷锟斤拷锟皆拷锟斤拷涔︼拷锟斤拷欠锟街瓜革拷锟斤拷锟缴拷锟�
6.锟斤拷锟斤拷维锟斤拷锟接碉拷锟阶ｏ拷Vitronection,VN锟斤拷
锟缴革拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷植锟斤拷锟斤拷锟轿拷锟斤拷拥锟斤拷锟斤拷锟斤拷疲锟斤拷锟斤拷薪锟较斤拷原锟侥癸拷锟杰★拷锟斤拷硬锟斤拷时锟街诧拷锟节斤拷原锟斤拷维锟斤拷锟斤拷锟侥诧拷位锟斤拷血锟斤拷VN水平锟酵革拷锟斤拷维锟斤拷锟教讹拷锟斤拷一锟斤拷锟斤拷锟斤拷锟斤拷浴锟�
7.锟斤拷锟斤拷锟斤拷锟斤拷锟阶ｏ拷Entactin,Nidogen锟斤拷
锟绞诧拷锟皆筹拷锟斤拷锟斤拷锟轿ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷拥锟斤拷锟斤拷锟斤拷牟锟轿伙拷锟斤拷锟斤拷锟斤拷怨锟斤拷奂锟斤拷锟较ｏ拷锟接讹拷锟斤拷锟节猴拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷慕锟较★拷锟斤拷植锟斤拷筒锟斤拷锟斤拷锟斤拷椎牡锟轿伙拷锟斤拷疲锟斤拷锟揭拷植锟斤拷诨锟斤拷锟侥わ拷锟�
锟斤拷锟斤拷锟斤拷锟斤拷锟阶讹拷锟角ｏ拷Proteoglycan锟斤拷
锟斤拷锟阶讹拷锟斤拷锟斤拷一锟斤拷锟缴碉拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥骨架ｏ拷锟斤拷N锟斤拷O位锟斤拷锟斤拷锟斤拷锟角帮拷锟斤拷锟角ｏ拷
Glycosaminoglycan,GAG锟斤拷锟斤拷锟斤拷锟侥达拷锟斤拷锟斤拷锟斤拷剩锟斤拷锟斤拷锟斤拷虢涸伙拷锟街诧拷锟斤拷细锟斤拷锟斤拷锟斤拷屎突锟斤拷锟侥わ拷希锟酵币诧拷植锟斤拷锟较革拷锟侥わ拷稀锟斤拷锟斤拷前锟斤拷锟斤拷强煞锟轿拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷兀锟紿eparan Sulfate锟斤拷锟斤拷锟斤拷锟斤拷皮锟斤拷锟截ｏ拷Dermatan Sulfate锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟截ｏ拷Chondroitin Sulfate锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷兀锟終eratan Sulfate锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟截猴拷锟斤拷锟斤拷啵硷拷锟斤拷锟斤拷锟紾AG锟斤拷60%锟斤拷锟斤拷锟斤拷维锟斤拷时锟戒含锟斤拷锟铰斤拷锟斤拷锟斤拷锟斤拷锟斤拷皮锟斤拷锟截猴拷锟斤拷锟斤拷锟斤拷锟斤拷锟截的猴拷锟斤拷锟斤拷锟接★拷透锟斤拷锟斤拷锟结（Hyaluronic Acid锟斤拷锟斤拷一锟斤拷锟斤拷亩锟斤拷牵锟轿达拷锟斤拷锟斤拷嗖伙拷锟斤拷锟斤拷坠羌堋锟斤拷锟斤拷锟斤拷呀锟斤拷锟斤拷嗟帮拷锥锟斤拷呛锟斤拷牡锟斤拷椎锟絚DNA锟斤拷隆锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷学锟斤拷锟杰碉拷锟剿斤拷也锟斤拷锟斤拷锟斤拷锟诫。锟斤拷锟斤拷锟斤拷植锟斤拷锟酵拷锟斤拷锟缴斤拷锟斤拷锟阶讹拷锟角凤拷为锟斤拷锟洁：
1.锟斤拷细锟斤拷膜锟斤拷氐牡锟斤拷锥锟斤拷锟�
锟斤拷锟斤拷牡锟斤拷锥锟斤拷锌锟侥わ拷锟斤拷锟斤拷锟斤拷锟斤拷械锟揭诧拷删锟斤拷锟紾AG锟斤拷锟斤拷锟斤拷细锟斤拷膜锟斤拷锟斤拷锟斤拷锟斤拷锟角猴拷锟叫达拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟截猴拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟截ｏ拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷省锟斤拷锟斤拷锟斤拷锟斤拷印锟较革拷锟秸筹拷锟斤拷锟斤拷樱锟紺AM锟斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷锟斤拷锟斤拷锟较ｏ拷使锟斤拷些锟斤拷锟绞的伙拷锟斤拷锟斤拷强锟斤拷锟斤拷锟斤拷锟�
Syndecan锟斤拷锟斤拷锟节革拷锟斤拷织锟斤拷锟斤拷锟斤拷锟叫的革拷细锟斤拷锟斤拷Hepatocyte锟斤拷锟斤拷锟斤拷一些细锟斤拷锟斤拷锟绞碉拷锟斤拷锟藉，锟斤拷通锟斤拷锟斤拷GAG锟斤拷锟斤拷锟斤拷瘛ⅱ蟆ⅱ锟斤拷徒锟皆拷锟斤拷锟轿拷锟斤拷岬帮拷准锟较革拷锟秸筹拷锟斤拷锟斤拷锟斤拷稀锟酵憋拷锟斤拷锟絙FGF锟侥革拷锟斤拷锟斤拷锟藉（Coreceptor锟斤拷锟斤拷锟斤拷锟斤拷要锟斤拷锟斤拷锟斤拷锟脚号达拷锟捷★拷
Thrombomodulin锟斤拷血锟斤拷锟斤拷皮细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷GAG锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟截★拷锟斤拷锟斤拷锟斤拷血酶锟斤拷希锟斤拷锟斤拷锟斤拷锟轿拷锟斤拷锟皆拷锟斤拷锟斤拷英锟斤拷募锟斤拷睿拷佣锟斤拷锟斤拷锟窖猴拷锟斤拷坦锟斤拷獭锟�
Betaglycan锟斤拷GAG锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟截猴拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟截★拷锟斤拷细锟斤拷膜锟斤拷锟藉，锟斤拷TGF-锟斤拷锟叫革拷锟阶猴拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥拷锟斤拷锟斤拷锟藉。
2.锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟截的碉拷锟阶讹拷锟斤拷
锟斤拷锟斤拷锟斤拷要锟街诧拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷小锟�
Fibromodulin锟斤拷GAG锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷兀锟斤拷锟斤拷缘锟斤拷诮锟皆拷锟轿拷锟斤拷纬伞锟斤拷诟锟斤拷锟斤拷锟斤拷锟轿达拷锟斤拷帧锟�
Perlecan锟缴凤拷实锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟街诧拷锟节伙拷锟斤拷膜锟酵碉拷锟杰★拷血锟杰★拷锟斤拷锟斤拷锟斤拷皮细锟斤拷锟酵革拷细锟斤拷锟斤拷稀锟�
Decorin锟斤拷 GAG锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟截猴拷锟斤拷锟斤拷皮锟斤拷锟截★拷锟斤拷锟斤拷瘛ⅱ锟斤拷锟皆拷锟斤拷锟轿拷锟斤拷岬帮拷捉锟较ｏ拷锟接伙拷锟斤拷原微锟斤拷维锟斤拷锟轿成★拷TGF-锟铰匡拷使Decorin锟侥憋拷锟斤拷锟斤拷锟接ｏ拷锟斤拷Decorin锟斤拷使TGF-锟斤拷锟斤拷睢ｏ拷诟锟斤拷锟轿拷锟斤拷锟斤拷锟斤拷脂细锟斤拷锟斤拷Decorin锟斤拷锟斤拷细撸锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷TGF-锟铰的伙拷锟皆ｏ拷锟斤拷锟斤拷失去维锟斤拷锟斤拷锟斤拷锟街革拷锟斤拷校锟紻ecorin锟侥憋拷锟斤拷锟斤拷伲锟斤拷锟斤拷锟斤拷TGF-锟铰碉拷锟斤拷锟狡硷拷锟斤拷锟斤拷
Biglycan锟斤拷GAG锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟截猴拷锟斤拷锟斤拷皮锟斤拷锟截ｏ拷锟斤拷锟斤拷脂细锟斤拷锟酵硷拷锟斤拷锟斤拷维细锟斤拷锟斤拷锟斤拷锟斤拷通锟斤拷锟斤拷锟斤拷牡锟斤拷锟斤拷锟絋GF-锟铰斤拷希锟酵拷锟斤拷锟紾AG锟斤拷bGFG锟斤拷稀锟絋GF-锟铰匡拷使锟斤拷锟斤拷锟斤拷锟斤拷撸锟斤拷锟轿拷锟斤拷锟斤拷使锟斤拷锟斤拷锟斤拷锟酵★拷
Versican锟斤拷锟斤拷锟轿拷锟斤拷锟斤拷锟斤拷锟斤拷兀锟絇DGF锟斤拷TGF-锟铰匡拷使锟斤拷锟斤拷锟斤拷锟斤拷印锟斤拷锟斤拷锟酵革拷锟斤拷锟斤拷锟斤拷稀锟斤拷锟轿慈凤拷锟斤拷锟斤拷锟较革拷锟斤拷欠锟缴诧拷锟斤拷Versican锟斤拷
锟斤拷锟侥ｏ拷细锟斤拷-锟斤拷锟斤拷粘锟斤拷锟斤拷锟接ｏ拷Cell-Matrix Adhension Molecules锟斤拷
细锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷食煞锟街拷锟侥凤拷锟斤拷锟洁互锟斤拷锟斤拷锟斤拷通锟斤拷锟截讹拷锟斤拷锟斤拷膜锟斤拷锟阶硷拷锟斤拷锟斤拷粘锟斤拷锟斤拷锟斤拷锟斤拷实锟街的★拷一些锟斤拷锟斤拷锟斤拷锟斤拷皮细锟斤拷锟斤拷锟斤拷皮细锟斤拷锟较撅拷锟斤拷锟斤拷锟斤拷锟秸筹拷锟斤拷锟斤拷樱锟斤拷锟斤拷锟斤拷锟斤拷锟较革拷锟斤拷锟窖拷锟斤拷皮细锟斤拷锟叫诧拷锟斤拷锟斤，锟斤拷锟斤拷锟斤拷维锟斤拷锟侥凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷些粘锟斤拷锟斤拷锟接的憋拷锟斤拷锟斤拷系锟斤拷锟経pregulation锟斤拷锟侥变。细锟斤拷一锟斤拷锟斤拷粘锟斤拷锟斤拷锟斤拷锟斤拷要锟斤拷锟斤拷Integrin锟斤拷庭锟斤拷CD44锟斤拷锟阶硷拷庭锟斤拷
1.Integrin
锟斤拷锟缴︼拷锟酵︼拷锟斤拷锟角癸拷锟桔革拷锟斤拷锟斤拷傻亩锟斤拷锟斤拷澹拷锟斤拷锟街拷锟�17锟街︼拷锟斤拷锟斤拷8锟街︼拷锟斤拷锟斤拷锟斤拷锟�21锟斤拷锟叫癸拷锟杰的讹拷锟斤拷锟藉。锟斤拷为锟斤拷锟斤拷Integrin锟斤拷锟皆斤拷隙锟斤拷锟斤拷锟斤拷澹拷锟揭伙拷锟较革拷锟斤拷锟斤拷锟绞成分匡拷锟缴讹拷锟斤拷Integrin通锟斤拷锟斤拷同锟斤拷识锟斤拷位锟斤拷锟较★拷锟斤拷锟斤拷要锟斤拷识锟斤拷位锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷史锟斤拷锟斤拷械锟絉-G-D锟斤拷锟斤拷-锟斤拷-锟届）锟斤拷锟叫ｏ拷锟斤拷锟斤拷锟絀ntegrin锟斤拷锟斤拷钥锟绞讹拷锟街拷锟斤拷锟斤拷锟絀ntegrin锟斤拷锟斤拷锟截讹拷锟斤拷锟斤拷织锟街诧拷锟斤拷一锟斤拷细锟斤拷锟斤拷锟皆达拷锟节讹拷锟斤拷Integrin锟斤拷锟斤拷锟斤拷锟斤拷识锟斤拷位锟斤拷锟斤拷锟斤拷锟斤拷氐锟斤拷锟斤拷诜羌锟斤拷锟较革拷锟斤拷希锟絀ntegrin锟街诧拷锟节革拷锟斤拷锟芥，锟节硷拷锟斤拷细锟斤拷只锟街诧拷锟斤拷锟斤拷锟斤拷锟酵诧拷锟芥。锟斤拷锟角诧拷锟斤拷锟斤拷粘锟斤拷锟斤拷锟矫ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟节癸拷锟斤拷锟斤拷锟斤拷细锟斤拷锟角硷拷锟斤拷锟斤拷锟斤拷锟绞匡拷锟皆达拷锟斤拷锟脚号ｏ拷锟劫斤拷细锟斤拷锟斤拷锟斤拷殖锟斤拷锟街伙拷锟斤拷锟斤拷锟叫★拷锟斤拷锟捷︼拷锟斤拷锟缴斤拷Integrin锟斤拷为3锟斤拷锟斤拷锟藉：
锟斤拷1锟斤拷10锟街ｏ拷锟斤拷锟斤拷3锟斤拷2锟街ｏ拷锟斤拷锟斤拷4锟斤拷1锟街ｏ拷锟斤拷锟斤拷要锟斤拷锟斤拷锟角介导细锟斤拷锟斤拷锟斤拷实锟秸筹拷锟斤拷锟斤拷植锟斤拷诖锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟诫胶原锟酵非斤拷原锟角碉拷锟阶斤拷希锟斤拷锟轿达拷锟斤拷锟斤拷锟斤拷锟斤拷氲帮拷锥锟斤拷墙锟较★拷
锟斤拷2锟斤拷3锟街ｏ拷锟斤拷锟斤拷7锟斤拷2锟街ｏ拷锟斤拷要锟斤拷锟斤拷锟斤拷锟较革拷锟斤拷榈硷拷锟斤拷锟较低筹拷锟较革拷锟斤拷锟较革拷锟街拷锟斤拷锟洁互锟斤拷锟矫★拷
锟斤拷6锟斤拷1锟街ｏ拷锟斤拷锟斤拷7锟斤拷1锟街ｏ拷锟斤拷锟斤拷8锟斤拷1锟街ｏ拷锟斤拷植锟斤拷锟轿э拷锟斤拷蓿锟斤拷锟斤拷锟斤拷胁锟斤拷锟斤拷锟斤拷
2.CD44锟斤拷锟阶硷拷锟斤拷
锟斤拷一锟斤拷锟斤拷锟斤拷腔锟斤拷锟斤拷目锟侥わ拷锟斤拷祝锟斤拷惴猴拷植锟斤拷锟斤拷锟较革拷锟斤拷锟斤拷锟斤拷越榈枷革拷锟�-细锟斤拷锟斤拷细锟斤拷-锟斤拷锟绞碉拷锟洁互锟斤拷锟矫★拷锟斤拷锟斤拷锟斤拷某锟皆憋拷锟杰多，锟斤拷锟斤拷锟斤拷状态锟铰ｏ拷锟斤拷细锟斤拷锟节硷拷獠伙拷锟紺D44锟斤拷锟阶的憋拷锟斤，锟斤拷锟斤拷血锟斤拷锟狡は革拷锟斤拷锌锟斤拷斜锟斤拷铩�
粘锟斤拷锟斤拷锟斤拷锟节革拷锟斤拷维锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥改憋拷锟角革拷细锟斤拷锟斤拷血锟斤拷锟狡は革拷锟斤拷盏锟斤拷锟斤拷锟絀ntegrin锟斤拷锟斤拷锟叫的诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟藉，锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷系锟斤拷谋锟斤拷锟斤拷诟锟接诧拷锟斤拷锟斤拷纬伞锟斤拷锟斤拷锟轿拷锟斤拷锟较革拷锟斤拷锟斤拷锟斤拷锟絋GF-锟铰和促斤拷锟斤拷症锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷TGF-锟斤拷锟斤拷IL-1锟铰★拷IFN-锟矫撅拷锟缴促斤拷Integrin锟斤拷锟斤拷锟紺D44锟斤拷锟阶的高憋拷锟斤。锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟轿ｏ拷Integrin锟斤拷锟斤拷锟斤拷盏锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷疲锟斤拷锟绞撅拷锟斤拷锟揭伙拷侄锟较革拷锟斤拷锟斤拷锟较革拷锟斤拷锟斤拷锟绞成分改憋拷姆锟斤拷锟斤拷锟斤拷苑锟接︼拷锟絀ntegrin锟斤拷锟斤拷募锟斤拷锟斤拷锟斤拷直锟接和硷拷拥卮锟斤拷锟揭幌碉拷械锟较革拷锟斤拷锟斤拷录锟斤拷锟斤拷锟较革拷锟斤拷锟斤拷锟教拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫伙拷锟斤拷锟斤拷凇锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟揭帮拷锟斤拷锟斤拷锟结化锟饺ｏ拷锟斤拷示细锟斤拷锟斤拷锟斤拷识锟斤拷诘锟斤拷诟锟较革拷锟斤拷锟窖拷锟斤拷皮细锟斤拷锟侥结构锟酵癸拷锟斤拷锟斤拷锟斤拷要锟斤拷锟矫★拷锟节革拷锟斤拷维锟斤拷锟斤拷锟斤拷锟节ｏ拷Integrin锟斤拷锟斤拷谋锟斤拷锟斤拷锟杰促斤拷细锟斤拷锟斤拷锟斤拷锟斤拷诰植锟斤拷某锟斤拷锟斤拷锟斤拷锟街拷锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷-锟斤拷锟斤拷粘锟斤拷锟斤拷锟接的憋拷锟斤拷锟较碉拷锟斤拷锟矫诧拷锟斤拷锟角讹拷细锟斤拷微锟斤拷锟斤拷锟侥憋拷锟斤拷锟接︼拷苑锟接︼拷锟斤拷锟斤拷液芸锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟轿拷锟斤拷锟斤拷锟斤拷墓锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷谩锟�
锟斤拷锟藉）锟斤拷锟绞斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷Matrix Metalloproteinases,MMP锟斤拷
细锟斤拷锟斤拷锟斤拷锟斤拷锟揭拷锟組MP锟斤拷锟斤拷锟解，锟斤拷目前为止锟窖凤拷锟斤拷锟斤拷9锟斤拷MMP锟斤拷锟斤拷锟斤拷锟斤拷锟矫碉拷锟斤拷牟锟酵拷煞锟轿拷锟皆革拷锟斤拷锟斤拷锟矫革拷锟斤拷锟斤拷史纸锟斤拷锟�3锟斤拷锟斤拷锟斤拷些锟斤拷锟绞斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷锟斤拷锟斤拷一锟斤拷锟斤拷锟斤拷锟斤拷澹拷锟斤拷堑慕峁癸拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷懈叨缺锟斤拷氐墓锟酵拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷嵌锟斤拷卸锟斤拷锟轿拷锟矫冈憋拷锟斤拷缘锟角帮拷墓锟斤拷锟斤拷锟斤拷锟斤拷锟絇RCGVPDV锟斤拷锟叫ｏ拷锟斤拷120锟斤拷锟斤拷锟斤拷锟斤拷锟絅锟剿癸拷锟斤拷锟斤拷锟皆硷拷锟竭伙拷位锟斤拷锟叫匡拷锟较癸拷锟斤拷锟斤拷锟斤拷锟斤拷HELGH锟斤拷锟叫ｏ拷锟斤拷锟斤拷锟绞斤拷锟斤拷锟斤拷锟斤拷酶锟侥碉拷锟节可凤拷锟斤拷锟节伙拷锟斤拷转录锟斤拷锟截★拷锟睫伙拷锟斤拷酶原锟侥硷拷锟筋及锟斤拷织锟斤拷锟斤拷锟斤拷锟斤拷驯锟斤拷锟斤拷锟矫革拷锟斤拷锟斤拷锟斤拷锟斤拷锟剿斤拷稀锟�
一些锟斤拷锟斤拷锟斤拷锟接★拷细锟斤拷锟斤拷锟接猴拷维锟斤拷锟结共同锟斤拷锟截讹拷锟街伙拷锟绞斤拷锟斤拷锟斤拷锟斤拷酶锟侥憋拷锟斤，锟斤拷些锟斤拷锟斤拷锟斤拷囟锟侥筹拷只锟斤拷式锟斤拷锟斤拷锟斤拷锟矫革拷谋锟斤拷锟斤拷械锟斤拷锟斤拷锟斤拷谩锟�
锟斤拷锟绞斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷锟斤拷锟睫伙拷锟皆碉拷酶原锟斤拷式锟斤拷锟节筹拷锟斤拷锟侥ｏ拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟较讹拷芯锟斤拷锟剿拷饧わ拷锟斤拷锟杰斤拷锟斤拷细锟斤拷锟斤拷锟斤拷省锟斤拷锟矫革拷锟斤拷锟矫冈拷锟斤拷锟斤拷铮║rokinase-plasminogen Activator,UPA锟斤拷锟斤拷锟斤拷织锟斤拷锟斤拷酶原锟斤拷锟斤拷锟斤（Tissue-plasminogen Activator,TPA锟斤拷锟斤拷锟斤拷锟斤拷酶原转锟斤拷为锟斤拷锟斤拷酶锟斤拷锟斤拷锟斤拷酶锟劫硷拷锟斤拷锟斤拷史纸锟斤拷兀锟斤拷锟斤拷旨锟斤拷罱涸盖帮拷澹拷锟斤拷锟斤拷锟斤拷锟侥伙拷锟绞分斤拷锟斤拷锟街斤拷一锟斤拷锟斤拷锟筋胶原酶锟斤拷锟斤拷一锟斤拷锟斤拷锟斤拷俨锟较低筹拷艿锟斤拷锟斤拷锟矫冈拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟�-1锟斤拷PAI-1锟斤拷锟侥碉拷锟节★拷锟较成伙拷锟绞斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷细锟斤拷锟斤拷锟斤拷同时也锟较筹拷锟斤拷锟斤拷酶原锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟接ｏ拷锟皆凤拷止锟斤拷锟绞的癸拷锟饺斤拷锟解。
锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷织锟斤拷锟斤拷锟斤拷锟接ｏ拷Tissue Inhibitor of Metalloproteinases,TIMP锟斤拷
锟窖撅拷锟斤拷锟斤拷幕锟斤拷式锟斤拷锟斤拷锟斤拷锟矫革拷锟较革拷锟斤拷锟斤拷隙锟斤拷锟杰碉拷锟斤拷锟斤拷锟皆斤拷锟斤拷锟斤拷锟斤拷酶锟斤拷织锟斤拷锟斤拷锟斤拷锟接的碉拷锟节★拷锟斤拷锟窖凤拷锟斤拷锟斤拷锟斤拷TIMP锟斤拷每锟斤拷TIMP锟斤拷锟斤拷锟斤拷呋锟斤拷锟轿恢憋拷咏锟较讹拷锟斤拷锟斤拷锟斤拷锟叫伙拷锟绞斤拷锟斤拷锟斤拷锟斤拷酶锟侥伙拷锟皆ｏ拷锟斤拷TIMP-1锟斤拷要锟斤拷锟狡硷拷锟斤拷锟皆斤拷原酶锟斤拷锟斤拷锟绞分斤拷锟截猴拷锟斤拷锟斤拷酶B锟斤拷92KD 锟斤拷锟酵斤拷原酶锟斤拷锟斤拷TIMP-2锟斤拷要锟斤拷锟斤拷锟斤拷锟斤拷酶A锟斤拷72KD 锟斤拷锟酵斤拷原酶锟斤拷锟斤拷锟斤拷锟斤拷址锟斤拷锟絋IMP锟斤拷锟杰猴拷某些锟斤拷锟斤拷锟斤拷锟斤拷酶原锟斤拷锟饺伙拷末锟剿斤拷隙锟斤拷锟街癸拷浔伙拷锟斤拷睢�
锟斤拷锟竭ｏ拷细锟斤拷锟斤拷锟接ｏ拷Cytokines锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟接ｏ拷Growth Factors锟斤拷
细锟斤拷锟斤拷锟斤拷士锟斤拷锟轿拷锟斤拷锟较革拷锟斤拷锟斤拷雍锟斤拷锟斤拷锟斤拷锟斤拷拥某锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟较革拷锟斤拷锟斤拷锟绞成分凤拷锟斤拷锟侥憋拷时锟斤拷通锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟秸筹拷锟斤拷锟斤拷佣锟较革拷锟斤拷锟斤拷拥幕锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟矫ｏ拷细锟斤拷锟斤拷锟斤拷锟街可促斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷实暮铣苫蚪到狻�
锟斤拷. 细锟斤拷锟斤拷锟斤拷实锟较革拷锟斤拷锟皆�
锟斤拷锟斤拷细锟斤拷锟斤拷Liver Cells锟斤拷锟缴凤拷为锟斤拷锟劫革拷实锟斤拷细锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷Hepatocyte锟斤拷锟斤拷锟节凤拷实锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷脂细锟斤拷锟斤拷Ito细锟斤拷锟斤拷锟斤拷血锟斤拷锟狡は革拷锟斤拷锟終upffer细锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷Pit Cell锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷织锟斤拷学锟斤拷锟斤拷锟斤拷原位锟接斤拷锟叫撅拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷实锟斤拷锟皆达拷锟斤拷私隙锟斤拷锟剿解。锟斤拷前锟斤拷锟斤拷为锟斤拷原锟斤拷要锟缴革拷细锟斤拷锟较成ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷要锟斤拷锟斤拷脂细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟揭拷锟斤拷锟街革拷锟斤拷锟斤拷锟斤拷锟� |
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