| 1963锟斤拷Blumberq锟斤拷锟斤拷锟斤拷锟斤拷谓锟斤拷锟斤拷锟窖拷锟斤拷频牟锟斤拷锟窖拷锟斤拷校锟斤拷锟斤拷锟揭伙拷锟斤拷斐ｏ拷目锟斤拷澹拷锟斤拷锟斤拷锟揭伙拷锟斤拷拇锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷说锟窖拷锟斤拷锟斤拷锟斤拷锟斤拷应锟斤拷直锟斤拷1967锟斤拷锟斤拷锟饺凤拷锟斤拷挚锟皆拷锟斤拷锟斤拷透锟斤拷祝锟斤拷锟斤拷锟揭肝ｏ拷锟叫关ｏ拷1970锟斤拷锟节碉拷锟斤拷锟斤拷微锟斤拷锟铰观察到HBV锟斤拷锟斤拷态锟斤拷1986锟疥将锟斤拷锟斤拷锟斤拷锟饺革拷DNA锟斤拷锟斤拷锟狡★拷
一锟斤拷锟斤拷态锟斤拷峁�
锟斤拷锟斤拷1锟斤拷锟斤拷锟斤拷锟轿匡拷锟斤拷锟斤拷锟斤拷锟紻ane锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷一锟斤拷锟斤拷一锟斤拷锟斤拷膜锟斤拷一锟斤拷锟斤拷锟斤拷DNA锟斤拷锟接的猴拷锟铰匡拷锟斤拷傻牟锟斤拷锟斤拷锟斤拷锟斤拷锟街憋拷锟皆�42nm锟斤拷锟斤拷锟铰匡拷为20锟斤拷锟斤拷猿平峁癸拷锟斤拷锟斤拷锟侥猴拷锟铰匡拷只锟斤拷锟节革拷细锟斤拷锟斤拷锟节观察到锟斤拷血锟斤拷Dane锟斤拷锟斤拷浓锟斤拷锟皆硷拷锟皆革拷锟斤拷潜锟斤拷锟节猴拷锟斤拷为锟斤拷撸锟斤拷诩锟斤拷锟斤拷锟绞硷拷锟斤拷锟窖革拷锟斤拷陆锟斤拷锟� Dane锟斤拷锟斤拷锟斤拷锟芥含锟斤拷 HBsAg 锟斤拷锟斤拷锟斤拷锟叫伙拷锟斤拷锟斤拷双锟斤拷锟斤拷缺锟节碉拷DNA锟斤拷锟斤拷锟斤拷锟斤拷DNA锟斤拷DNA锟斤拷锟矫革拷锟侥壳帮拷锟轿狣ane锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷HBV锟斤拷
锟斤拷锟斤拷HBV DNA锟斤拷锟斤拷锟斤拷锟斤拷锟教诧拷一锟斤拷锟斤拷锟斤拷锟斤拷L锟斤拷锟斤拷锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟饺恒定锟斤拷约3200锟斤拷锟斤拷锟斤拷锟结。锟斤拷锟斤拷锟斤拷S锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟饺可变，约为锟斤拷锟斤拷锟斤拷锟饺碉拷50锟斤拷100%锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷5锟斤拷-3锟斤拷顺锟斤拷锟斤拷小锟斤拷诓锟酵拷锟斤拷锟斤拷卸锟斤拷锟�3锟斤拷说锟轿伙拷锟斤拷强杀锟侥ｏ拷锟斤拷锟斤拷锟斤拷锟酵筹拷锟斤拷锟斤拷5锟斤拷锟轿伙拷霉潭锟斤拷锟轿筹拷锟侥╋拷耍锟酵拷锟�250锟斤拷300锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷裕锟斤拷锟轿拷锟紻NA锟斤拷锟接的伙拷状锟结构锟斤拷锟斤拷粘锟斤拷末锟斤拷锟斤拷锟洁，锟斤拷锟斤拷5锟斤拷烁锟斤拷锟揭伙拷锟斤拷锟�11锟斤拷bp锟斤拷傻锟街憋拷锟斤拷馗锟斤拷锟斤拷锟� (Direct repeat DR)-5锟斤拷TTCACCTCTCC锟斤拷锟斤拷DR位锟节碉拷1824锟斤拷锟斤拷锟斤拷锟斤拷锟竭筹拷DR1锟斤拷位锟节碉拷1590锟斤拷锟斤拷锟斤拷锟斤拷锟竭筹拷DR2锟斤拷锟节诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟矫★拷
锟斤拷锟斤拷2锟斤拷小锟斤拷锟斤拷锟斤拷锟斤拷锟街憋拷锟皆�22nm锟斤拷小锟斤拷锟轿匡拷锟斤拷锟斤拷HBV锟斤拷染锟斤拷血液锟斤拷锟斤拷锟斤拷锟斤拷一锟街★拷锟斤拷锟斤拷HBsAg锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷膜锟斤拷伞锟斤拷锟窖э拷锟斤拷为脂锟斤拷锟阶ｏ拷锟缴帮拷锟斤拷锟斤拷锟叫碉拷锟杰讹拷锟斤拷锟斤拷锟斤拷血锟藉蛋锟阶诧拷锟街凤拷锟诫。锟节此匡拷锟斤拷锟斤拷未锟斤拷锟斤拷锟紻NA锟斤拷锟矫革拷锟斤拷浴锟侥壳帮拷锟轿狧BV锟斤拷小锟斤拷锟斤拷锟斤拷锟斤拷HBV锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷染锟斤拷细锟斤拷时锟较成癸拷剩锟斤拷锟斤拷膜锟斤拷锟斤拷锟斤拷锟斤拷血循锟斤拷锟叫★拷
锟斤拷锟斤拷3.锟斤拷锟轿匡拷锟斤拷锟斤拷直锟斤拷约22nm锟斤拷锟斤拷锟饺匡拷锟斤拷100锟斤拷700nm之锟戒。实锟斤拷锟斤拷锟斤拷锟斤拷一锟斤拷锟桔猴拷锟斤拷锟斤拷锟斤拷小锟斤拷锟斤拷锟斤拷锟斤拷同锟斤拷锟斤拷锟斤拷HBsAg锟侥匡拷原锟皆★拷
锟斤拷锟斤拷锟斤拷锟斤拷峁�
锟斤拷锟斤拷目前锟斤拷锟窖可从革拷染HBV锟斤拷锟剿碉拷血锟斤拷锟叫硷拷锟斤拷染锟斤拷锟斤拷锟结纯锟侥诧拷锟斤拷锟斤拷锟斤拷锟叫凤拷锟斤拷锟斤拷锟阶此拷锟紻NA锟斤拷锟接讹拷确锟斤拷HBV锟斤拷DNA锟斤拷锟斤拷锟斤拷锟叫撅拷Dane锟斤拷锟斤拷DNA锟结构锟斤拷锟街ｏ拷DNA锟斤拷锟接猴拷锟斤拷约3锟斤拷200锟斤拷锟斤拷锟斤拷锟结。锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷一锟斤拷锟斤拷锟饺固讹拷锟侥革拷锟斤拷锟斤拷锟斤拷一锟斤拷锟饺诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷DNA锟斤拷锟斤拷铣锟斤拷锟斤拷诙锟斤拷酶锟斤拷锟斤拷DNA锟斤拷锟斤拷锟斤拷锟斤拷末锟斤拷 3锟戒－OH锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟�5'-锟斤拷锟斤拷锟斤拷纬锟斤拷锟斤拷锟斤拷脂锟斤拷锟斤拷傻模锟斤拷锟剿ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷5'-3'顺锟斤拷锟斤拷校锟斤拷锟斤拷壹拥锟斤拷锟斤拷系锟矫匡拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷前锟侥ｏ拷锟紻NA锟侥硷拷锟斤拷锟皆伙拷锟斤拷锟斤拷锟缴斤拷锟叫ｏ拷锟斤拷锟斤拷锟斤拷1,800锟斤拷1,818锟斤拷锟斤拷锟结附锟斤拷锟斤拷一锟斤拷锟斤拷品锟斤拷锟斤拷锟斤拷锟斤拷5'-末锟斤拷通锟斤拷锟斤拷锟斤拷250-300锟斤拷锟斤拷锟斤拷锟斤拷募锟斤拷锟斤拷远锟轿拷址锟斤拷拥幕锟阶达拷峁癸拷锟紻NA锟斤拷锟矫革拷锟斤拷貌锟斤拷锟斤拷映锟斤拷锟斤拷锟�3锟斤拷锟斤拷锟斤拷薏锟饺憋拷凇锟饺憋拷诳锟斤拷锟斤拷锟紿BV锟斤拷DNA锟节革拷染细锟斤拷锟节碉拷锟斤拷锟斤拷锟叫关★拷
锟斤拷锟斤拷目前锟斤拷锟斤拷锟节匡拷隆锟斤拷DNA锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟窖撅拷确锟斤拷锟斤拷锟斤拷锟斤拷证实HBsAg锟斤拷HBcAg锟斤拷锟斤拷锟斤拷Dane锟斤拷锟斤拷锟斤拷DNA锟斤拷锟斤拷锟诫，锟斤拷锟揭讹拷锟斤拷锟斤拷锟斤拷锟斤拷同一DNA锟斤拷锟斤拷锟较★拷锟斤拷锟剿比较诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷筒锟斤拷锟斤拷锟斤拷伲锟斤拷锟斤拷锟紿BV DNA锟斤拷锟斤拷锟杰憋拷锟斤拷全锟斤拷锟斤拷知锟斤拷HBV锟斤拷锟斤拷锟绞ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟脚讹拷锟斤拷锟斤拷锟斤拷锟斤拷锟杰憋拷锟诫病锟斤拷锟斤拷锟阶★拷
锟斤拷锟斤拷HBV DNA锟斤拷锟斤拷锟斤拷锟侥革拷锟斤拷锟斤拷锟斤拷锟斤拷锟街憋拷锟轿猄锟斤拷C锟斤拷P锟斤拷X锟斤拷图26-2锟斤拷锟斤拷锟杰憋拷锟斤拷全锟斤拷锟斤拷知锟斤拷HBV锟斤拷锟斤拷锟绞★拷S锟斤拷锟缴凤拷为锟斤拷锟斤拷锟街ｏ拷S锟斤拷锟斤拷锟角癝锟斤拷锟斤拷S锟斤拷锟津（猴拷锟斤拷锟斤拷155锟斤拷833锟斤拷锟杰憋拷锟斤拷锟斤拷要锟斤拷锟芥蛋锟阶★拷S锟斤拷锟斤拷之前锟斤拷一锟斤拷锟杰憋拷锟斤拷163锟斤拷锟斤拷锟斤拷锟结（2锟斤拷848-154锟斤拷锟斤拷前S锟斤拷锟津，憋拷锟斤拷Pre S1锟斤拷Pre S2锟斤拷锟阶★拷C锟斤拷锟斤拷锟斤拷锟斤拷锟角癈锟斤拷锟斤拷锟紺锟斤拷锟津，分憋拷锟斤拷锟紿BeAg锟斤拷HBcAg锟斤拷P锟斤拷锟筋长锟斤拷约占锟斤拷锟斤拷锟斤拷75%锟斤拷锟较ｏ拷锟斤拷锟诫病锟斤拷锟斤拷DNA锟斤拷锟矫革拷锟絏锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷1锟斤拷374锟斤拷1锟斤拷835锟斤拷锟斤拷锟杰憋拷锟斤拷锟斤拷154锟斤拷锟斤拷锟斤拷锟斤拷募锟斤拷远锟斤拷模锟斤拷锟斤拷锟斤拷锟斤拷芽锟轿伙拷诖锟斤拷锟斤拷锟�
锟斤拷锟斤拷HBV锟侥匡拷原锟斤拷锟�
锟斤拷锟斤拷1.HBsAg锟斤拷HBsAg锟斤拷锟斤拷HBV锟侥伙拷锟斤拷锟斤拷锟斤拷锟截讹拷锟侥ｏ拷为锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷态锟侥匡拷锟斤拷锟斤拷锟斤拷锟叫★拷HBsAg 锟斤拷原锟斤拷锟斤拷锟斤拷锟节高革拷锟斤拷锟杰度凤拷围锟节碉拷脂锟斤拷锟斤拷锟洁。锟斤拷CsCl锟杰讹拷锟捷讹拷锟斤拷锟侥ｏ拷锟斤拷锟芥抗原锟斤拷小锟斤拷锟斤拷锟酵癸拷状锟斤拷锟斤拷锟斤拷平锟斤拷锟杰讹拷为1.20g/cm2锟斤拷Dane锟斤拷锟斤拷锟斤拷锟杰讹拷锟皆高ｏ拷为1.25g/cm2锟斤拷锟斤拷锟斤拷锟斤拷22nm锟斤拷锟斤拷锟斤拷平锟斤拷锟斤拷锟斤拷系锟斤拷为33-54S锟斤拷锟斤拷锟斤拷锟斤拷约为24-2.5锟斤拷106锟斤拷锟斤拷锟斤拷锟斤拷HBsAg 锟斤拷锟斤拷锟斤拷脂锟绞★拷锟斤拷锟洁、脂锟绞★拷锟斤拷锟斤拷锟绞硷拷锟角碉拷锟阶★拷锟斤拷锟斤拷8锟街讹拷锟斤拷锟斤拷桑锟斤拷锟斤拷锟轿狿1锟斤拷P8锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫讹拷锟街伙拷锟斤拷锟街讹拷锟侥癸拷锟斤拷锟斤拷Schiff锟斤拷锟斤拷锟斤拷锟皆ｏ拷锟斤拷示锟斤拷锟斤拷锟斤拷锟斤拷峁癸拷锟斤拷锟斤拷锟斤拷锟街癸拷锟饺计硷拷锟斤拷锟饺★拷锟紿BsAg锟斤拷锟斤拷示锟叫碉拷锟酵的碉拷锟斤拷锟斤拷锟秸癸拷锟阶★拷锟斤拷锟斤拷占锟斤拷锟斤拷锟斤拷70锟斤拷90%锟斤拷锟较ｏ拷锟斤拷锟斤拷锟紿BsAg 锟斤拷锟斤拷锟街碉拷锟斤拷锟斤拷桑锟�
锟斤拷锟斤拷锟斤拷1锟斤拷锟斤拷要锟斤拷锟芥蛋锟阶ｏ拷S锟斤拷锟阶ｏ拷小锟斤拷锟斤拷HBsAg锟斤拷锟斤拷锟斤拷S锟斤拷锟斤拷锟斤拷锟斤拷226锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷伞锟�
锟斤拷锟斤拷锟斤拷2锟斤拷锟叫凤拷锟接碉拷锟阶ｏ拷锟叫凤拷锟斤拷 HBsAg锟斤拷锟斤拷锟斤拷前S2锟斤拷S锟斤拷锟斤拷锟斤拷耄拷锟絊锟斤拷锟斤拷226锟斤拷锟斤拷锟斤拷锟斤拷锟絅锟剿革拷锟斤拷一锟斤拷锟斤拷55锟斤拷锟斤拷锟斤拷锟斤拷锟� Pre S2锟斤拷锟斤拷锟斤拷桑锟斤拷锟�281锟斤拷锟斤拷锟斤拷锟结。
锟斤拷锟斤拷锟斤拷3锟斤拷锟斤拷锟斤拷拥锟斤拷祝锟斤拷锟斤拷锟斤拷HBsAg锟斤拷锟斤拷锟斤拷S锟斤拷前S1锟斤拷前S2 锟斤拷锟斤拷锟斤拷耄拷锟斤拷蟹锟斤拷拥锟斤拷锟�281锟斤拷锟斤拷锟斤拷锟斤拷锟絅锟剿革拷锟斤拷一锟斤拷锟斤拷119锟斤拷锟斤拷锟斤拷锟斤拷锟� Pre S1锟斤拷锟斤拷锟斤拷桑锟斤拷锟�400锟斤拷锟斤拷锟斤拷锟结。
锟斤拷锟斤拷S锟斤拷锟阶硷拷锟斤拷锟斤拷HBsAg锟斤拷锟斤拷HBV锟斤拷膜锟斤拷锟斤拷要锟斤拷锟芥抗原锟斤拷锟斤拷要锟缴份ｏ拷锟斤拷锟斤拷锟角伙拷锟斤拷锟斤拷GP27锟酵凤拷锟角伙拷锟斤拷锟斤拷P24锟斤拷锟斤拷锟斤拷式锟斤拷锟皆讹拷锟斤拷锟斤拷锟斤拷锟斤拷纬啥锟斤拷锟斤拷澹拷锟斤拷锟紿BsAg锟侥结构锟斤拷位锟斤拷锟竭憋拷锟斤拷锟斤拷锟侥匡拷原锟皆★拷锟斤拷锟斤拷锟斤拷锟斤拷锟诫，锟斤拷HBsAg锟斤拷原锟皆斤拷锟斤拷锟斤拷锟斤拷锟铰斤拷锟斤拷HBsAg 锟杰刺硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟接︼拷锟斤拷濉拷锟紿BS锟斤拷锟斤拷锟斤拷HBV锟斤拷锟叫和匡拷锟藉，锟斤拷锟斤拷锟斤拷锟竭憋拷锟斤拷锟斤拷锟矫ｏ拷HBsAg锟侥硷拷锟斤拷锟紿BV锟斤拷染锟侥憋拷志之一锟斤拷
锟斤拷锟斤拷前S锟斤拷锟斤拷2(Pre S2)锟斤拷锟斤拷C锟斤拷HBsAg锟斤拷锟斤拷锟斤拷锟斤拷Pre S2锟斤拷露锟斤拷HBV锟斤拷膜锟斤拷悖拷锟斤拷卸锟斤拷锟斤拷血锟斤拷椎锟斤拷锟� (Polymenized Human Serum Albumin,PHSA)锟斤拷锟斤拷锟藉（PHSA-R锟斤拷锟斤拷锟斤拷锟斤拷PH-SA锟斤拷稀锟斤拷锟斤拷诟锟较革拷锟斤拷锟斤拷锟揭诧拷锟絇HSA-R锟斤拷HBV锟斤拷通锟斤拷血循锟斤拷锟叫达拷锟节碉拷PHSA锟侥介导锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟芥，锟斤拷缶锟斤拷锟斤拷锟斤拷媒锟斤拷锟斤拷细锟斤拷锟节★拷锟界病锟斤拷血锟斤拷锟叫硷拷锟絇re S2锟斤拷锟斤拷示HBV锟节革拷细锟斤拷锟叫革拷锟狡★拷Pre S2锟斤拷锟斤拷锟矫碉拷锟斤拷锟斤拷原锟皆ｏ拷锟杰刺硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟接︼拷锟斤拷濉拷锟絇re S2锟斤拷锟剿匡拷锟斤拷锟斤拷锟斤拷诩锟斤拷愿锟饺撅拷指锟斤拷锟斤拷冢锟斤拷瓤锟紿Bs锟斤拷锟斤拷锟斤拷锟轿拷锟绞憋拷锟斤拷肟笻Bs一锟斤拷锟斤拷锟斤拷Pre S2锟斤拷锟斤拷锟叫猴拷锟斤拷锟矫ｏ拷锟斤拷锟斤拷为锟斤拷锟藉康锟斤拷锟斤拷指锟斤拷之一锟斤拷
锟斤拷锟斤拷Pre S1锟叫斤拷强锟斤拷锟斤拷原锟皆ｏ拷锟斤拷锟斤拷锟斤拷强Pre S2锟斤拷HBsAg 锟斤拷锟斤拷锟斤拷原锟皆ｏ拷Pre S1锟教硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟接︼拷锟斤拷濉狿re S1锟斤拷锟矫匡拷锟斤拷锟斤拷lgM锟斤拷lgG锟斤拷锟街ｏ拷锟斤拷锟叫匡拷Pre S1锟斤拷HBV锟斤拷染潜锟斤拷锟节ｏ拷也锟斤拷锟斤拷锟节匡拷HBV锟斤拷lgM锟斤拷锟斤拷前锟窖诧拷锟斤拷锟斤拷锟绞匡拷锟斤拷为HBV锟斤拷锟节革拷染锟斤拷锟斤拷锟斤拷锟斤拷指锟疥。锟斤拷锟斤拷Pre S1 lgG锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷维锟斤拷时锟斤拷铣锟斤拷锟斤拷锟斤拷锟斤拷泻锟斤拷锟斤拷谩锟�
锟斤拷锟斤拷HBsAg锟斤拷一些锟劫斤拷锟斤拷锟皆的伙拷锟斤拷锟斤，锟斤拷锟斤拷锟窖★拷1锟斤拷1锟饺凤拷一锟斤拷锟截★拷十锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷啤锟斤拷锟斤拷锟�30锟皆硷拷锟斤拷锟街碉拷锟斤拷水锟斤拷酶锟斤拷锟斤拷锟饺讹拷锟斤拷HBsAg锟斤拷锟斤拷锟斤拷锟铰凤拷锟斤拷锟斤拷小时锟皆猴拷锟饺讹拷锟斤拷锟节硷拷锟斤拷锟铰ｏ拷锟戒冻锟节伙拷锟斤拷锟斤拷使锟斤拷锟斤拷睢ｏ拷锟斤拷锟斤拷锟斤拷脂锟绞匡拷锟杰讹拷锟斤拷一些锟斤拷要锟缴碉拷锟斤拷锟斤拷傻目锟皆拷锟斤拷锟斤拷锟斤拷鸨；锟斤拷锟斤拷谩锟紿BsAg锟斤拷锟叫硷拷锟斤拷锟斤拷锟斤拷锟皆匡拷原锟斤拷郑锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷凸锟酵拷锟皆拷锟斤拷锟斤拷锟斤拷锟斤拷a,锟酵讹拷锟介互锟斤拷锟脚筹拷锟斤拷锟斤拷途锟斤拷锟斤拷锟絛/y锟斤拷 w/r锟斤拷HBsAg锟斤拷锟斤拷要锟斤拷锟斤拷锟斤拷adr锟斤拷adw锟斤拷ayr锟斤拷ayw4锟街★拷欧锟斤拷锟斤拷锟斤拷adr锟斤拷为锟斤拷锟斤拷锟揭癸拷锟斤拷锟斤拷锟斤拷adr锟接讹拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟揭癸拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絘yw为锟斤拷锟斤拷锟斤拷锟截★拷锟铰斤拷锟斤拷锟斤拷锟缴等ｏ拷锟斤拷
锟斤拷锟斤拷2锟斤拷HBcAg锟斤拷HBcAg锟斤拷锟斤拷锟斤拷Dane锟斤拷锟斤拷锟侥猴拷锟侥猴拷锟斤拷锟酵革拷锟阶伙拷锟竭的革拷细锟斤拷锟斤拷锟节★拷 HBcAg一锟斤拷锟紿BcAg锟斤拷锟斤拷尸锟斤拷位锟绞碉拷锟斤拷染锟侥猴拷锟斤拷锟缴革拷锟斤拷锟斤拷取锟斤拷锟斤拷锟斤拷锟酵革拷锟阶的硷拷锟斤拷锟节★拷锟街革拷锟节猴拷HBcAg携锟斤拷锟斤拷锟叫筹拷锟缴诧拷锟斤拷锟斤拷锟紿Bc锟斤拷锟剿匡拷锟斤拷圆锟斤拷锟斤拷锟斤拷泻锟斤拷锟斤拷谩锟斤拷锟斤拷锟斤拷绶拷锟紿BcAg锟津抗★拷HBc锟斤拷示HBV锟节革拷锟节筹拷锟斤拷锟斤拷锟狡★拷
锟斤拷锟斤拷3锟斤拷HBeAg锟斤拷锟叫癸拷e锟斤拷原锟侥憋拷锟绞伙拷锟斤拷十锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟轿拷锟斤拷锟角憋拷卮锟斤拷锟斤拷锟紻ane锟斤拷锟斤拷锟侥猴拷锟侥诧拷锟街★拷锟斤拷目前为止锟斤拷锟斤拷未锟斤拷HbsAg锟斤拷锟皆碉拷血锟斤拷锟叫筹拷锟街癸拷锟斤拷 HBeAg锟斤拷一锟斤拷锟斤拷锟皆匡拷原锟斤拷锟斤拷原锟斤拷知锟斤拷锟斤拷锟斤拷锟斤拷锟酵ｏ拷e1锟斤拷e2锟斤拷e3锟斤拷锟斤拷锟斤拷HBeAg锟斤拷DNA锟斤拷锟矫革拷锟窖猴拷械锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷HBcAg锟侥达拷锟节匡拷锟斤拷为锟斤拷锟斤拷锟斤拷HBV锟斤拷锟狡硷拷血锟斤拷锟斤拷写锟饺撅拷缘锟揭伙拷直锟角ｏ拷血锟斤拷HBsAg锟轿讹拷越锟竭ｏ拷HBeAg锟侥硷拷锟斤拷锟斤拷锟斤拷锟斤拷摺锟斤拷锟叫╋拷锟斤拷丝沙锟斤拷锟斤拷锟紿Be锟斤拷锟藉，锟斤拷锟斤拷也锟斤拷一锟斤拷锟叫憋拷锟斤拷锟斤拷锟矫的匡拷锟藉。
锟侥★拷HBV锟斤拷锟斤拷锟斤拷
锟斤拷锟斤拷HBV锟斤拷锟斤拷织锟斤拷锟斤拷锟斤拷未锟缴癸拷锟斤拷锟斤拷然锟斤拷锟斤拷锟斤拷锟斤拷展锟剿达拷锟斤拷锟竭肝伙拷玫姆只锟脚革拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷票锟斤拷锟斤拷锟斤拷锟斤拷烁锟较革拷锟较碉拷锟斤拷锟斤拷锟皆肝达拷锟斤拷锟斤拷锟斤拷锟侥筹拷锟斤拷锟斤拷锟斤拷织锟侥凤拷锟斤拷锟斤拷锟斤拷应锟矫革拷锟街革拷锟斤拷织锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷HBV锟皆猴拷锟斤拷锟窖★拷锟斤拷锟斤拷锟矫革拷锟斤拷细锟斤拷锟斤拷锟斤拷锟劫凤拷锟斤拷HBV锟侥大胆筹拷锟皆ｏ拷锟斤拷锟揭恍╋拷锟斤拷锟斤拷状锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟绞癸拷锟斤拷锟斤拷锟街拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷没锟斤拷一锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷HBV锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷取HBV DNA锟斤拷锟叫达拷染锟斤拷通锟斤拷细锟斤拷锟节猴拷锟斤拷锟斤拷锟饺诧拷锟斤拷锟斤拷途锟斤拷锟斤拷锟斤拷HBV锟斤拷锟斤拷未锟矫碉拷锟斤拷锟较的斤拷锟斤拷锟斤拷戏锟窖э拷撸锟�1976锟斤拷锟斤拷锟斤拷锟剿达拷一锟斤拷HBsAg锟斤拷锟斤拷原锟斤拷锟皆肝帮拷锟斤拷织锟斤拷锟斤拷锟斤拷细锟斤拷系锟斤拷PLC/PRF/5锟斤拷锟斤拷锟揭碉拷HBsAg锟侥革拷锟狡★拷锟斤拷细锟斤拷系锟斤拷锟斤拷要锟截碉拷锟斤拷锟杰诧拷锟斤拷HBsAg 锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷104/锟斤拷细锟斤拷锟缴诧拷锟斤拷500ng HBsAg 锟斤拷锟斤拷锟竭电镜锟斤拷示锟斤拷锟斤拷锟轿�22nm锟侥匡拷锟斤拷锟斤拷锟斤拷为圆锟轿ｏ拷锟斤拷锟斤拷锟斤拷微锟结构锟斤拷锟戒抗原锟斤拷锟斤拷锟斤拷锟斤拷锟皆撅拷锟斤拷血液锟叫碉拷HBsAg锟斤拷同锟斤拷未锟斤拷锟斤拷Dane锟斤拷锟斤拷锟斤拷锟斤拷锟轿★拷目前锟斤拷锟斤拷细锟斤拷系锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷模锟酵★拷锟斤拷锟斤拷锟斤拷锟斤拷HBV锟斤拷锟阶感讹拷锟斤，锟斤拷锟斤拷锟斤拷筛锟饺撅拷锟斤拷锟斤拷锟角帮拷锟斤拷锟斤拷小锟斤拷锟斤拷锟斤拷煤锟斤拷锟斤拷锟斤拷芯锟紿BV锟侥凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷远锟斤拷锟斤拷摺锟斤拷锟斤拷锟斤拷锟斤拷叩锟叫э拷锟斤拷约锟紿BV锟斤拷锟斤拷陌锟饺拷浴锟斤拷锟斤拷锟斤拷锟斤拷傻锟斤拷锟皆达拷锟饺憋拷锟斤拷锟斤拷怨惴河︼拷谩锟�
锟藉、锟街匡拷锟斤拷
锟斤拷锟斤拷HBV锟斤拷锟斤拷锟侥抵匡拷锟斤拷锟斤拷强锟斤拷锟皆碉拷锟铰★拷锟斤拷锟斤、锟斤拷锟斤拷锟竭猴拷一锟姐化学锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟杰★拷锟揭肝诧拷锟斤拷锟侥达拷染锟皆猴拷HBsAg锟侥匡拷原锟斤拷锟节讹拷锟斤拷锟街匡拷锟斤拷锟斤拷锟斤拷锟斤拷全一锟铰★拷锟斤拷锟斤拷锟斤拷37锟斤拷锟斤拷锟斤拷锟斤拷维锟斤拷7锟届，锟斤拷-20锟斤拷锟缴憋拷锟斤拷20锟疥，100锟斤拷锟斤拷锟斤拷10锟斤拷锟接匡拷使HBV失去锟斤拷染锟斤拷锟斤拷锟斤拷锟皆可憋拷锟街憋拷锟芥抗原锟斤拷锟皆★拷HBV锟斤拷0.5%锟斤拷锟斤拷锟斤拷锟结、5%锟斤拷锟斤拷锟狡猴拷3%漂锟阶凤拷锟斤拷锟叫ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷 |
